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159 results found


Gynecologic Cancer, Ovarian cancer

Ubamatamab in Platinum-Resistant Ovarian Cancer

The purpose of this study is to evaluate an investigational drug called ubamatamab in patients who have advanced ovarian cancer. Researchers want to determine how safe, tolerable, and effective ubamatamab is on its own and ...


Colon

Optimizing Body Weight With TCMCB07 in Patients With Newly Diagnosed Metastatic Colorectal Cancer Undergoing Chemotherapy

This study focuses on people with advanced colorectal cancer. The purpose of the study is to evaluate an experimental treatment called TCMB07 (B07) that may help cancer patients gain and/or maintain their weight while they ...


Colon, Liver, Lung, Other Digestive Organ, Other Female Genital, Pancreas ...

VS-7375 in Advanced KRAS G12D-Mutant Solid Tumors

This study focuses on people who have been diagnosed with a solid tumor that contains a specific change (mutation) in the KRAS gene. One common mutation in KRAS is called G12D; participants in this study ...


Colon, Liver, Lung, Pancreas, Rectum, Small Intestine, Stomach, Unknown Sites

Zanzalintinib vs Everolimus in Locally Advanced or Metastatic Neuroendocrine Tumors

The purpose of this study is to evaluate the effectiveness of an experimental drug called zanzalintinib compared to the standard-of-care treatment, everolimus, in treating people with locally advanced or metastatic neuroendocrine tumors. Zanzalintinib is a ...


Breast

RLY-2608 + Fulvestrant Versus Capivasertib + Fulvestrant as Treatment for HR+/HER2- Metastatic Breast Cancer

This study focuses on people who have metastatic (spread to other areas of the body) hormone receptor-positive, human epidermal growth factor 2-negative (HR+/HER2-) breast cancer that has a mutation in a gene called PIK3CA. The ...