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Eplontersen in Transthyretin-Mediated Amyloid Cardiomyopathy

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called eplontersen in people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). ATTRCM is a disease caused by change in a protein ...


Pregnancy without an Associated Complication

The HEALthy Brain and Child Development (HBCD) Study

Leading researchers in the fields of child development and neuroscience will work with participating families and their children to learn how children develop early in life. This study will help us learn more about child development ...


Other

Functional Characterization of Post-Heart Transplant De Novo Donor Specific Antibodies

The purpose of this study is to identify unique characteristics of pathological donor-specific antibodies (DSAs). Pathological DSAs cause injury to the transplanted heart (also known as graft injury), unlike DSAs that may have attained immunological ...


Cardiomyopathy - ischemic

Canadian CABG or PCI in Patients with Ischemic Cardiomyopathy (STICH3C)

This study focuses on people who have multivessel coronary artery disease (blockages in the blood vessels supplying the heart muscle) and ischemic left ventricular dysfunction (weak heart from reduced coronary blood flow secondary to the ...


Other Hematopoietic

Cemacabtagene Ansegedleucel in Large B-Cell Lymphoma

This study focuses on individuals with large B-cell lymphoma who have completed initial therapy. The study aims to determine whether CAR T cells made from healthy donors are an effective treatment to prevent relapse in ...