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Sparsentan Treatment in Pediatric Subjects

The purpose of this study is to determine the safety and effectiveness of an investigational drug called sparsentan in the treatment of kidney diseases and whether it is safe to use in children who are ...


Other

Edwards SAPIEN 3 Transcatheter Pulmonary Valve System with Alterra Adaptive Prestent

The purpose of this study is to evaluate the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Pulmonary Valve System with the Alterra Adaptive Prestent, which is approved by the U.S. Food and Drug ...


Brain and Nervous System

Carboplatin and Vincristine Versus Selumetinib in Low-Grade Glioma

This study focuses on individuals who have been diagnosed with a cancer called low-grade glioma (LGG). The purpose of the study is to determine whether an experimental drug called selumetinib is as effective as the ...


Hand ligament reconstruction surgery

Hand Ligament Reconstructions With Knee Collateral Ligament Allografts

The purpose of this study is to review clinical outcomes following hand ligament reconstruction surgery using allograft (cadaveric) knee collateral ligaments. Researchers believe that the use of allograft ligaments may eliminate the pain associated with ...


Familial hypercholesterolemia

Bempedoic Acid in Pediatric Patients With Heterozygous Familial Hypercholesterolemia

The purpose of this study is to evaluate the investigational use of a drug called bempedoic acid in individuals who have heterozygous familial hypercholesterolemia (HeFH). HeFH is a condition in which there are higher-than-normal amounts ...