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Optimizer Smart PAS

The MDAC panel recommended a post-approval study that evaluates data such as cardiac outcomes, quality of life, mortality, and functionality. Long term data are also needed to assess complication rates and potential interactions with other ...


Inflammatory Bowel Disease

CORALE - IBD

This study focuses on individuals who are at least 13 years old and have inflammatory bowel disease (Crohn's disease or ulcerative colitis). The purpose of the study is to understand the effects of COVID-19 vaccination ...


Pancreas

Johns Hopkins University; EIIT2020-Osipov; Ph 2; OL; PDAC; Pembrolizumab with or without Defactinib

This study focuses on patients who have been recently diagnosed with high-risk pancreatic cancer and whose cancer was determined to be surgically removable (resectable). The purpose of the study is to evaluate the effectiveness (anti-tumor ...


Larynx, Lip, Oral Cavity and Pharynx

Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Cancer of the Head and Neck

The purpose of this study is to determine whether post-operative radiation therapy with the drugs docetaxel and cetuximab, or post-operative radiation therapy with cisplatin and an immunotherapy drug, atezolizumab, is better than the usual approach ...


Breast, Rectum

CSMC, IIT2020-26-FIGUEIREDO-TRE, cancer, time-restricted eating

This research will answer three key questions: (1) can TRE improve clinical outcomes, including treatment toxicity, patient-reported outcomes, and tumor regression (Aim 1) (2) do the underlying molecular mechanisms support the Differential Stress Sensitization theory ...