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Efruxifermin in Compensated Cirrhosis Due to NASH/MASH

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called efruxifermin (EFX) for the treatment of compensated liver cirrhosis due to nonalcoholic steatohepatitis (NASH)/metabolic dysfunction-associated steatohepatitis (MASH). NASH/MASH ...


Other

DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy

The purpose of this study is to evaluate safety and effectiveness of an experimental drug called DNTH103 for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP) when compared to a placebo (inactive substance). Participants are ...


Other

Oral Metformin Versus Injectable Insulin for the Treatment of Gestational Diabetes

Gestational diabetes mellitus (GDM) is one of the most widespread medical problems in pregnancy. The most common medication is insulin, which requires daily injections; another option is metformin, which is an oral pill. The purpose ...


Prostate

Epigenetic Therapy Before Prostatectomy in Men With Prostate Cancer

This study focuses on people who have prostate cancer and are planning to have a radical prostatectomy (removal of prostate and some surrounding tissue). The purpose of the study is to assess the safety, tolerability, ...


Breast

PF-07220060 in Combination With Letrozole in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

This study focuses on people who have hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer and have not received any systemic anti-cancer treatment for their disease. The ...