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159 results found

Melanoma, Other Skin, Other Urinary, Ovary, Unknown Sites

IMC-F106C in Advanced Cancers

The purpose of this study is to determine the safety and effectiveness of an investigational immunotherapeutic drug called IMC-F106C in multiple cancers (endometrial, ovarian, melanoma, ocular melanoma, triple-negative breast, lung, and bladder cancer) expressing a ...

Leukemia, not otherwise specified

Inotuzumab Ozogamicin for Newly Diagnosed High-Risk B-ALL

This study focuses on individuals who have been diagnosed with mixed-phenotype acute leukemia (MPAL). MPAL is a cancer of the white blood cells that occurs in the bone marrow and is a rare form of ...

Melanoma, Soft Tissue

Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Melanoma

Substudies 02A, 02B, and 02C: To assess the safety and tolerability of investigational treatment combinations based on the proportion of participants with adverse events (AEs). Substudies 02A and 02B: To evaluate objective response rate (ORR) as assessed ...

Anus, Brain and Nervous System, Breast, Cervix, Colon, Corpus Uteri ...

LNS8801 in Patients With Advanced Cancer

This study focuses on patients with locally advanced or metastatic cancer (solid tumor or lymphoma) whose cancer has not improved and for whom there are no additional standard treatment options. The purpose of the study ...


CSMC, IIT2019-09-GONG-MCRPC, Prostate, role of glutamine metabolism on progression

Aim 1. Determine the potential of plasma glutamine as a prognostic and predictive biomarker in patients with PCa Aim 1A. Evaluate whether plasma glutamine and eukaryotic translation initiation factor 4E-binding protein 1 (p-4E-BP1, a downstream target ...