Find Clinical Trials | Cedars-Sinai

23 results found

✔ Specialty: Digestive & Liver

Other

Induction Therapy with PRA023 in Ulcerative Colitis

This study focuses on individuals with ulcerative colitis (UC) that has been assessed as being moderate to severe. The purpose of the study is to determine whether an investigational drug called PRA023 is safe and ...

Liver

Exact Science, ALTUS2021-01, at Risk for Hepatocellular Ca (HCC), Multi-Target Test Oncoguard

Primary Objective: Assess overall sensitivity and specificity of Oncoguard Liver for hepatocellular cancer (HCC) detection in a surveillance population. Secondary Objective(s): Assess performance of Oncoguard Liver in confirmed HCC and non-HCC population. Assess early-stage sensitivity of Oncoguard Liver ...

Other

Primary objective: 1. To investigate the effect of treatment with oral linerixibat compared with placebo on itch in PBC patients with cholestatic pruritus over 24 weeks (Part A) Secondary objectives: 1. To evaluate the early effects of oral linerixibat compared to placebo on itch in PBC patients with cholestatic pruritus (Part A) 2. o characterize the effects of treatment with oral linerixibat compared with placebo on health related QoL (Part A) 3. To evaluate the effects of 24 weeks of treatment with oral linerixibat compared to placebo on itch response rates in PBC patients with cholestatic pruritus (Part A) 4. To investigate the treatment effect of oral linerixibat compared with placebo on Patient’s Global Impression of Severity (PGI-S) and Patient’s Global Impression of Change (PGI-C) throughout the treatment period (Part A) 5. o evaluate the effects of treatment with linerixibat on markers of PBC disease activity and progression (Part A) Safety: 1. To evaluate the safety of oral linerixibat compared with placebo (Part A and Part B) Exploratory: 1. To investigate the improvement, maintenance, or return of itch (Part B)

Cholestatic pruritus burdens up to three quarters of patients with PBC during the course of their disease. This itch due to this rare and chronic liver disease, represents a serious condition that continues to lack effective treatments. Linerixibat, ...

Other

Endoscopic Weight Loss Therapy: Clinical Outcomes Over One year of Follow-Up

The purpose of this study is to better understand the metabolic and hormonal effects of endoscopic bariatric therapy. Specifically, researchers will examine changes in weight, quality of life, and hormonal levels after various endoscopic bariatric ...

Obesity

Allurion Gastric Balloon System for the Treatment of Adults with Obesity

The purpose of this study is to evaluate the safety and potential advantages of an investigational device called the Allurion Gastric Balloon System (AGBS), which has been developed for the treatment of adult individuals who ...