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21 results found

✔ Specialty: Digestive & Liver


Induction Therapy with PRA023 in Ulcerative Colitis

This study focuses on individuals with ulcerative colitis (UC) that has been assessed as being moderate to severe. The purpose of the study is to determine whether an investigational drug called PRA023 is safe and ...


Exact Science, ALTUS2021-01, at Risk for Hepatocellular Ca (HCC), Multi-Target Test Oncoguard

Primary Objective: Assess overall sensitivity and specificity of Oncoguard Liver for hepatocellular cancer (HCC) detection in a surveillance population. Secondary Objective(s): Assess performance of Oncoguard Liver in confirmed HCC and non-HCC population. Assess early-stage sensitivity of Oncoguard Liver ...


Global Linerixibat Itch STudy of Efficacy and Safety iN PBC (GLISTEN)

Primary: To investigate the effect of treatment with oral linerixibat compared with placebo on itch in PBC patients with cholestatic pruritus over 24 weeks (Part A) Secondary: - To evaluate the early effects of oral linerixibat compared to ...



Co-Primary Effectiveness Endpoint 1: Responder Rate (RR) dichotomized at 5% TBWL at 48 weeks is significantly greater than 50%. Co-Primary Effectiveness Endpoint 2: Treatment Group mean %TBWL is significantly greater than Control Group mean %TBWL at 48 weeks, ...


Saroglitazar Magnesium in Primary Biliary Cholangitis

This study focuses on individuals who are 18-75 years old and have a confirmed diagnosis of primary biliary cholangitis (PBC). PBC is a progressive inflammatory disease leading to destruction of the bile ducts and scarring ...