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AZD3427 in Heart Failure and Pulmonary Hypertension Due to Left Heart Disease

The purpose of this study is to evaluate the effectiveness, safety, and tolerability of an experimental drug called AZD3427, given in addition to standard-of-care medication, in patients with heart failure and pulmonary hypertension due to ...


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SELUTION SLR 014 Drug Eluting Balloon in the Treatment of In-Stent Restenosis

The purpose of this study is to demonstrate whether an investigational device called the SELUTION SLR drug eluting balloon is well tolerated and whether it works as effectively as other currently available treatments for patients ...


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Functional Characterization of Post-Heart Transplant De Novo Donor Specific Antibodies

The purpose of this study is to identify unique characteristics of pathological donor-specific antibodies (DSAs). Pathological DSAs cause injury to the transplanted heart (also known as graft injury), unlike DSAs that may have attained immunological ...


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Early Feasibility Study of the Trisol System Protocol

The purpose of this study is to evaluate the safety and effectiveness of the experimental Trisol System (TRISOL Valve System) in people who have tricuspid regurgitation (TR). TR is a condition in which the heart’s ...


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HIS-Bundle Corrective Pacing in Heart Failure

The purpose of this study is to assess the effects of pacing-cardiac resynchronization therapy to a specific area of the heart called the His bundle (HIS-CRT), compared to biventricular pacemaker cardiac resynchronization therapy (BIV-CRT) on ...