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HIS-Bundle Corrective Pacing in Heart Failure

The purpose of this study is to assess the effects of pacing-cardiac resynchronization therapy to a specific area of the heart called the His bundle (HIS-CRT), compared to biventricular pacemaker cardiac resynchronization therapy (BIV-CRT) on ...


Other

Cerebral Protection in Transcatheter Aortic Valve Replacement

The purpose of this study is to evaluate the safety and feasibility of an experimental filter system called the ProtEmbo Cerebral Protection System (ProtEmbo Device) in patients who are undergoing TAVR and have a risk ...


Other

Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

This study focuses on people who have an existing bioprosthetic aortic valve that is failing and needs to be replaced and who fall in the high or greater risk category for open heart surgery. The ...


Other

PROGRESS Trial Continued Access Clinical Investigation Plan

The purpose of this study is to learn whether the SAPIEN 3 and SAPIEN 3 Ultra, and SAPIEN Ultra RESILIA Transcatheter Heart Valve are beneficial for patients with moderate, calcific aortic stenosis. Study procedures include ...


Cardiomyopathy - ischemic

Canadian CABG or PCI in Patients with Ischemic Cardiomyopathy (STICH3C)

This study focuses on people who have multivessel coronary artery disease (blockages in the blood vessels supplying the heart muscle) and ischemic left ventricular dysfunction (weak heart from reduced coronary blood flow secondary to the ...