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76 results found


Congenital heart

Medtronic Harmony TPV Post-Approval Study

The purpose of this study is to evaluate the functionality of transcatheter implantation (a minimally invasive procedure) of the Medtronic Harmony Transcatheter Pulmonary Valve (TPV). Significant pulmonary regurgitation (abnormal reversal of blood flow in the ...


Heart failure

Implantable CCM in the Heart Failure Group With Higher Ejection Fraction

The purpose of this study is to determine whether cardiac contractility modulation (CCM), a heart failure device therapy that improves contraction of the heart, will reduce cardiovascular mortality and heart failure hospitalizations in certain patients. ...


Other

Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

This study compares 2 methods of treating infants who were born prematurely with a patent ductus arteriosus (PDA). A PDA is a blood vessel connecting the lungs and the heart. All infants have a PDA ...


Other

MYK-224 in Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

The purpose of this study is to examine the safety and effectiveness of an investigational drug called MYK-224 in individuals with obstructive hypertrophic cardiomyopathy (oHCM). The amount of MYK-224 that reaches the blood stream and ...


Other

Coronary Sinus Reducer in Refractory Angina II (COSIRA-II)

The purpose of this study is to collect information on the safety and effectiveness of an investigational device called the Reducer for treatment of patients with refractory (persistent) angina. Angina is a type of chest ...