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Volumetric Echocardiographic Particle Image Velocimetry in Mitral Valve Regurgitation

The purpose of this study is to evaluate a technique to measure the severity of leakage of the mitral valve in people with mitral valve regurgitation. Mitral valve regurgitation is a condition which, if untreated ...


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Functional Characterization of Post-Heart Transplant De Novo Donor Specific Antibodies

The purpose of this study is to identify unique characteristics of pathological donor-specific antibodies (DSAs). Pathological DSAs cause injury to the transplanted heart (also known as graft injury), unlike DSAs that may have attained immunological ...


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Treprostinil Therapy to Reverse Right Ventricular Remodeling in Pulmonary Arterial Hypertension

The purpose of this study is to evaluate whether giving a drug called treprostinil earlier in a patient’s pulmonary arterial hypertension (PAH) diagnosis and then quickly increasing the dose will improve the patient’s PAH symptoms ...


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Early Feasibility Study of the Trisol System Protocol

The purpose of this study is to evaluate the safety and effectiveness of the experimental Trisol System (TRISOL Valve System) in people who have tricuspid regurgitation (TR). TR is a condition in which the heart’s ...


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HIS-Bundle Corrective Pacing in Heart Failure

The purpose of this study is to assess the effects of pacing-cardiac resynchronization therapy to a specific area of the heart called the His bundle (HIS-CRT), compared to biventricular pacemaker cardiac resynchronization therapy (BIV-CRT) on ...