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Aortic Stenosis: Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve

The purpose of this study is to determine whether an investigational device called the Sapien X4 Transcatheter Heart Valve system is beneficial for patients with symptomatic, severe, calcific aortic stenosis. Aortic stenosis is a condition ...


Triscuspid Regurgitation: Edwards PASCAL TranScatheter Valve Repair System

The purpose of this study is to evaluate the safety and effectiveness of an experimental device called the PASCAL System with optimal medical therapy (OMT) compared to OMT alone in patients with symptomatic severe tricuspid ...

Pulmonary hypertension

Pulmonary Hypertension: Sotatercept versus Placebo (CADENCE)

This study focuses on individuals who have been diagnosed with a form of pulmonary hypertension (PH) associated with left heart disease, known as heart failure with preserved ejection fraction (HFpEF). PH is a disease affecting ...

Familial hypercholesterolemia

Bempedoic Acid in Pediatric Patients With Heterozygous Familial Hypercholesterolemia

The purpose of this study is to evaluate the investigational use of a drug called bempedoic acid in individuals who have heterozygous familial hypercholesterolemia (HeFH). HeFH is a condition in which there are higher-than-normal amounts ...


Medtronic Harmony TPV Post-Approval Study

The purpose of this study is to evaluate the functionality of transcatheter implantation (a minimally invasive procedure) of the Medtronic Harmony Transcatheter Pulmonary Valve (TPV). Significant pulmonary regurgitation (abnormal reversal of blood flow in the ...