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Comparative Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy

The purpose of this study is to compare 2 commonly used doses of aspirin to prevent hypertensive (high blood pressure) disorders of pregnancy (HDP) in women who are pregnant and at risk of having HDP. ...


Other

The KAPP-Sen Tissue Mapping Center (TMC) Collaborative

The purpose of this study is to understand the role of senescent cells. A senescent cell is a cell that ages and permanently stops dividing but does not die. Researchers want to learn how these ...


Other

Oral Metformin Versus Injectable Insulin for the Treatment of Gestational Diabetes

Gestational diabetes mellitus (GDM) is one of the most widespread medical problems in pregnancy. The most common medication is insulin, which requires daily injections; another option is metformin, which is an oral pill. The purpose ...


Other

Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease

The purpose of this study is to evaluate the effectiveness of an experimental drug called tirzepatide for the treatment of Crohn’s disease. Participants will be randomly assigned to 1 of 2 groups. Group 1 will ...


Obesity

Evaluating Environmental Control (AVOID) and Inhibitory Control (RESIST) Strategies to Improve Weight Management Outcomes

This study tests strategies to help adults with overweight or obesity (BMI between 25-45 kg/m2) “stick” to weight management recommendations. Specifically, the study evaluates the benefit of 2 self-regulatory approaches to improve intentional weight loss ...