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135 results found


Lung, Rectum

HPN328 in Advanced Cancers Associated with DLL3

The purpose of this study is to test the safety and effects of an experimental drug called HPN328 alone and in combination with another drug, atezolizumab, in patients who have small cell lung cancer or ...


Breast

Shorter Anthracycline-Free Chemo Immunotherapy in Early Triple-Negative Breast Cancer

The purpose of this study is to compare the standard-of-care chemo-immunotherapy (carboplatin/paclitaxel followed by adriamycin/cyclophosphamide plus pembrolizumab, given in 6 months) treatment for early-stage, triple-negative breast cancer to a shorter non-anthracycline chemo-immunotherapy treatment (carboplatin docetaxel ...


Breast, Cervix, Colon, Esophagus, Kidney, Liver, Lung, Melanoma, Other Female ...

GIM-122 as a Single Agent in Advanced Solid Malignancies

The purpose of this study is to evaluate an investigational drug called GIM-122 in people who have been diagnosed with an advanced or malignant tumors. These patients have tumors that were eligible to be treated ...


Colon, Rectum

Metastatic Colorectal Cancer: Evaluating Radiation, Ablation, and Surgery

This study focuses on individuals who have advanced colorectal cancer that has spread up to 4 body sites. The purpose of the study is to compare the usual treatment alone to ablative local therapy (ALT) ...


Breast

Elacestrant in Various Combinations in Metastatic Breast Cancer

The purpose of this study is to determine whether an endocrine therapy drug approved by the U.S. Food and Drug Administration (FDA) called elacestrant is safe and effective when given in combination with one of ...